Role of serum response factor expression in prostate cancer biochemical recurrence
نویسندگان
چکیده
منابع مشابه
Impact of biochemical recurrence in prostate cancer among US veterans.
BACKGROUND Among men treated for prostate cancer, increasing prostate-specific antigen (PSA) is known as biochemical failure or biochemical recurrence (BCR). The impact of BCR on subsequent mortality is uncertain, however, especially given competing causes of death. METHODS To describe patterns of BCR and subsequent mortality, we conducted an observational study in a community-based, "high-co...
متن کاملCirculating Tumor Cells in Biochemical Recurrence of Prostate Cancer.
OBJECTIVE Circulating tumor cells (CTCs) have known prognostic implications in metastatic castration-resistant prostate cancer, but little is known regarding its utility in biochemical recurrence (BR) of prostate cancer. The primary objectives were to determine whether CTCs are measurable in patients with BR and whether it can reliably predict prostate-specific antigen (PSA) increase and PSA do...
متن کاملThe analysis of serum response factor expression in bone and soft tissue prostate cancer metastases.
BACKGROUND Castration-resistant prostate cancer (CRPC) represents a challenge to treat with no effective treatment options available. We recently identified serum response factor (SRF) as a key transcription factor in an in vitro model of castration resistance where we showed that SRF inhibition resulted in reduced cellular proliferation. We also demonstrated an association between SRF protein ...
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Due to a lack of sufficient diagnostic tools to predict aggressive disease, there is a significant overtreatment of patients with prostate cancer. Platelet derived growth factors (PDGFs) and their receptors (PDGFRs) are key regulators of mesenchymal cells in the tumor microenvironment, and has been associated with unfavorable outcome in several other cancers. Herein, we aimed to investigate the...
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1Department of Oncology, Wayne State University, Detroit, MI 48201-1379, USA 2Department of Urology, Wayne State University, Detroit, MI 48201, USA 3Department of Medicine, University of Illinois at Chicago, Chicago, IL 60607-4067, USA 4Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7335, USA 5 Integrated Cancer Genomics Division, The Translational G...
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ژورنال
عنوان ژورنال: The Prostate
سال: 2018
ISSN: 0270-4137
DOI: 10.1002/pros.23516